There’s something truly comforting about layers of creamy sauce wrapped up in tender pasta. This Creamy Chicken Alfredo Lasagna Roll-Ups Recipe combines rich Alfredo sauce, shredded chicken, and gooey mozzarella in a way that feels fancy but is surprisingly easy to make. Trust me, it’s a dish that will impress dinner guests and satisfy family appetites all at once.

A close-up of a single piece of lasagna roll up being lifted by a wooden spatula, showing three layers of wavy-edged pasta sheets filled with creamy white cheese sauce that is smooth and dripping slightly. The top layer is browned cheese with slight crisped texture and sprinkled scattered small green herbs. The inside cheese sauce has a soft, velvety look with tiny black pepper dots visible, making the dish look rich and cheesy. The background shows more lasagna rolls on a white marbled surface, blurred softly. Photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

I’m genuinely obsessed with how this recipe delivers creamy, cheesy goodness without feeling heavy or fussy. It’s like the best parts of chicken Alfredo and lasagna got together and decided to throw a party in your oven. Plus, it comes together faster than traditional lasagna, which is a win in my book!

Convenience: The roll-ups cook faster than layered lasagna, perfect for busy weeknights or last-minute dinners.
Flavor Combo: Creamy Alfredo sauce paired with tender chicken and mozzarella creates rich, comforting layers every bite.
Portion Control: Each roll-up is perfectly sized for individual servings — no battling over the last piece.
Make Ahead Friendly: You can fully assemble these ahead of time and bake them when you’re ready, saving time on busy days.

A white rectangular dish holds a baked pasta casserole with three visible layers. The bottom layer shows a creamy, pale yellow sauce with chunks of light-colored filling. On top of this are soft, flat pasta sheets, slightly ruffled on the edges, forming the middle layer. The top layer is a golden-brown melted cheese blanket with spots of darker caramelization and a sprinkle of finely chopped green herbs spread evenly. The dish sits on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

Each ingredient plays its part to make this dish irresistibly creamy and packed with flavor. I’ve found that using quality cheeses and fresh ingredients really elevates it. Here are my thoughts on what you’ll need:

Flat lay of uncooked flat, wide lasagna noodles arranged neatly beside three whole uncracked garlic cloves with fresh papery skins, a small white ceramic bowl filled with creamy white butter chunks, a small white bowl containing a mound of fine all-purpose flour, two small white bowls—one with smooth whole milk and the other with thick heavy whipping cream, a small white bowl heaped with grated pale parmesan cheese, a small white bowl holding finely shredded white mozzarella cheese, a pile of shredded cooked chicken breast with natural texture, a small white bowl sprinkled with coarse ground black pepper, a small white bowl with fine salt crystals, a tiny white bowl with ground nutmeg powder, and a few fresh green parsley sprigs for garnish, all arranged in perfect symmetry on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodles: Opt for regular or no-boil noodles; I prefer cooking regular ones just until al dente for the best roll-up texture.
Butter: It’s the base for the roux that thickens the Alfredo sauce and adds richness.
Garlic: Freshly minced adds aroma and depth; don’t rush this step!
All-purpose flour: Helps thicken the sauce to that perfect creamy consistency.
Milk and heavy cream: The combo gives Alfredo that smooth, luscious texture—whole milk works best if you can get it.
Parmesan cheese: Freshly grated is a must for authentic flavor and the perfect melt.
Salt, pepper & nutmeg: Seasonings that bring balance—especially that hint of nutmeg, which is classic in Alfredo and adds warmth.
Cooked shredded chicken: Use leftovers or rotisserie chicken for quick prep and guaranteed tenderness.
Mozzarella cheese: Provides the melty, stretchy factor that makes these roll-ups extra indulgent.
Fresh parsley: For a bright, fresh garnish that cuts through the richness and adds color.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

One of the best things about this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe is how easy it is to adapt. I love playing with different cheeses or adding in veggies to suit whatever I have in the fridge.

Vegetable boost: I sometimes sneak in finely chopped spinach or mushrooms into the chicken mixture—it adds nutrition and extra flavor without complicating the dish.
Spicy kick: A pinch of red pepper flakes in the Alfredo sauce gives it a subtle heat that my family loves.
Increased protein: Swap shredded chicken for cooked sausage or a blend of both for a heartier version.
Dairy-free twist: Use lactose-free milk and a vegan cheese alternative; just expect a slightly different texture but still delicious.

Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Cook the Noodles Perfectly

Start by boiling your lasagna noodles in salted water just until they’re al dente — usually about 8 to 10 minutes, but check your package instructions. After draining, I like to transfer them to a pot with room temperature water to keep them from sticking. This little trick saved me more than once from battling a big sticky noodle mess!

Step 2: Whip Up the Creamy Alfredo Sauce

In a saucepan over medium heat, melt butter and gently sauté minced garlic until fragrant — don’t let it brown, about a minute. Stir in the flour and cook for another minute to form a roux. Slowly whisk in the milk and heavy cream, then simmer the sauce for about 2 minutes. Stir in freshly grated Parmesan, salt, pepper, and nutmeg if you’re using it. Keep whisking until the sauce thickens and cheese melts into a silky, silky sauce. If it gets too thick, just whisk in a splash of milk.

Step 3: Mix Chicken and Cheese Filling

Take one cup of your freshly made Alfredo sauce and stir it into shredded chicken and mozzarella cheese. This makes a creamy, cheesy filling that’s bursting with flavor. Season with a little more salt and pepper to taste—I always taste as I go here.

Step 4: Roll ’Em Up and Bake

Spoon a thin layer of Alfredo sauce (about half a cup) on the bottom of a greased 9x13-inch baking dish—this keeps the roll-ups from sticking. Lay out a noodle, spread the chicken and cheese filling evenly over it, then roll it up tightly. Place each roll seam-side down in the pan. Pour the remaining Alfredo sauce over the top, sprinkle with leftover mozzarella, and bake at 375°F (190°C) for about 25-30 minutes until bubbly and golden brown on top.

Top Tip

From personal experience, nailing the sauce consistency and noodle texture is what makes or breaks this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe. Getting these just right means every bite is smooth, cheesy, and perfectly tender.

Keep noodles moist: Don’t let cooked noodles dry out; the trick is to keep them submerged in room temperature water until you're ready to roll. It saves a lot of frustration.
Don’t rush sauce thickening: Give the Alfredo sauce enough time to simmer gently—this is what brings that silky texture and rich flavor.
Room temperature ingredients: Use room temp milk and cream to prevent lumps when making your sauce smoothly.
Roll close, but not tight: Rolling noodles snugly but not forcing them keeps the filling inside without tearing the pasta.

How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Chicken Alfredo Lasagna - Serving Suggestion

Garnishes

I love sprinkling a handful of freshly chopped parsley right after baking—it adds a fresh pop of color and light herbal flavor that lifts the creamy richness beautifully. For extra indulgence, a small dusting of more Parmesan on top always hits the spot.

Side Dishes

To keep things balanced, I usually go with a crisp green salad dressed with a tangy vinaigrette or some roasted veggies like asparagus or broccoli. Garlic bread is a lovely indulgent side if you want to keep it classic Italian comfort food.

Creative Ways to Present

For a special dinner, I’ve arranged the roll-ups standing slightly angled around a circular platter with fresh basil leaves tucked in between for a beautiful presentation. Drizzling a little extra Alfredo sauce on the side and garnish makes it feel restaurant-worthy without the fuss.

Make Ahead and Storage

Storing Leftovers

I let leftovers cool completely before covering them tightly with foil or plastic wrap and storing in the fridge. They keep well for 3 to 4 days, and flavors often deepen overnight so the next day’s meal is just as good, if not better.

Freezing

This dish freezes wonderfully! I fully assemble the roll-ups in a freezer-safe dish, cover it tightly with foil, and freeze. When ready to bake, thaw overnight in the fridge and bake a bit longer to warm all the way through.

Reheating

To reheat, pop individual roll-ups in the microwave covered with a damp paper towel for a minute or two, or warm the whole dish in a 350°F oven until heated through and bubbly again. This keeps the sauce luscious and the cheese melty.

Frequently Asked Questions:

Can I use store-bought Alfredo sauce for this recipe?

Absolutely! Using store-bought Alfredo sauce can save time, but I suggest enhancing it with a bit of extra Parmesan cheese and fresh garlic for that homemade flavor kick.

How can I make this dish vegetarian?

Swap the shredded chicken for sautéed mushrooms, spinach, or a mix of your favorite veggies. You might want to add a little more cheese or cream to keep it extra creamy and satisfying.

Can I prepare the roll-ups earlier and bake later?

Yes! You can assemble the roll-ups a day ahead, cover tightly with foil, and keep them in the refrigerator. When ready, just bake them according to the instructions, adding a few extra minutes if they're chilled.

What sides go well with Creamy Chicken Alfredo Lasagna Roll-Ups?

Fresh green salads, roasted vegetables, or even garlic bread complement the richness of this dish perfectly. For a lighter touch, a citrusy arugula salad is also fantastic.

Final Thoughts

This Creamy Chicken Alfredo Lasagna Roll-Ups Recipe has become one of my go-to comfort meals, especially when I want something that feels special but doesn’t consume my whole afternoon. It’s perfect for gathering around the table, sharing warm smiles and sauces-soaked napkins. Give it a try—you’ll be amazed how easy it is to create that rich, cheesy magic right in your own kitchen.