Name: Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Prep time: 30 min
Cook time: 35 min
Total time: 1 h 5 min
Cuisine: American
Ingredients: 12 lasagna noodle sheets; 3 chicken breasts (thighs, cutlets or tenders work too); 4 tablespoons olive oil; 2 tablespoons cajun seasoning (see seasoning recipe below); 1/2 block cream cheese, softened; 1 15 oz ricotta cheese; 12 oz frozen chopped spinach (drained well); prepared chicken, diced; 1 8 oz block mozzarella (shredded, divided); 1 8 oz block colby jack cheese (shredded, divided); 2-3 teaspoons cajun seasoning; 6 tablespoons butter; 6-8 large cloves garlic, minced; 2 cups heavy whipping cream; 1-2 teaspoons cajun seasoning; 1 cup grated parmesan cheese; salt and pepper to taste; 2 tablespoons smoked paprika (regular paprika works too); 1 tablespoon cayenne pepper; 1 tablespoon onion powder; 2 teaspoons brown sugar; 2 teaspoons garlic powder; 1 teaspoon ground black pepper; 1 teaspoon salt; 1/2 teaspoon dried thyme; 1/2 teaspoon dried oregano; garlic bread or Texas toast for serving

There’s something so irresistible about creamy, cheesy comfort food with a little kick, which is exactly why the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe has become one of my absolute go-tos. It’s like the best of lasagna and chicken alfredo rolled into one delicious, satisfying bite.

A white rectangular baking dish filled with a creamy baked dish showing three visible layers: a melted golden brown cheese topping with bubbly texture and some browned spots, a thick white creamy sauce layer mixed with herbs visible as green flecks, and a soft, pale base layer which is partly covered by the sauce. A woman’s hand is lifting a portion from the dish, causing long stretches of melted cheese to drip down, and the top is sprinkled with small pieces of fresh green herbs. The dish sits on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

When I first tried making this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe, I was hooked immediately — the amazing flavor combo of blackened spices mixed with creamy, garlicky alfredo made every bite something to savor. Plus, it’s surprisingly approachable to make at home.

Bold flavors balanced with creamy richness: The blackened chicken packs just enough spice, while the alfredo sauce is silky and cheesy without being heavy.
Fun and impressive presentation: Lasagna roll-ups look fancy but are easier to portion and serve than a big lasagna tray.
Vegetables sneak in effortlessly: The spinach melts into the cheese mixture, adding color and nutrition without overwhelming flavors.
Great make-ahead potential: You can prep the roll-ups in advance, then bake just before serving to save time.

A creamy baked dish shown in a white ceramic casserole dish placed on a white marbled surface, with a slice being lifted by a fork. The slice has three visible layers: a melted golden-brown cheese top with browned spots and green herbs, a thick middle layer of creamy, cheesy white sauce with small green herb flecks and a smooth texture, and a soft bottom layer visible where the slice is separated. The sauce drips slightly from the slice, showing a rich and gooey consistency. photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

This recipe is all about combining distinct layers that bring harmony together. Each ingredient plays a key role — from the herbs and spices that create that irresistible blackened chicken flavor, to the cheesy filling and creamy sauce that binds it all up beautifully.

Flat lay of twelve uncooked rectangular lasagna noodle sheets stacked neatly, three raw chicken breasts with fresh pink flesh, small white ceramic bowls containing golden olive oil, rich creamy heavy whipping cream, and bright red smoked paprika powder, a small white bowl with vibrant deep red cayenne pepper, a small white bowl with light beige onion powder, another with brown sugar crystals, a small white bowl holding pale garlic powder, one with coarse ground black pepper, a small white bowl of fine salt, dried thyme and oregano sprigs beside them, a half block of smooth, soft cream cheese, a rectangular block of shredded white mozzarella cheese, a block of shredded orange Colby Jack cheese, a round mound of white ricotta cheese, a handful of dark green chopped spinach leaves, several large uncracked brown eggs with clean shells, and a few fresh garlic cloves both whole and minced on the side, all arranged in perfect symmetry on a simple white ceramic plate and bowls, placed on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodle sheets: Make sure to cook them al dente so they hold up rolling without cracking.
Chicken breasts (or thighs/cutlets): Thighs add more juiciness, but chicken breast works great too for leaner protein.
Olive oil: For searing the chicken and adding richness without overpowering flavors.
Cajun seasoning: This homemade blend (see recipe below) provides that signature blackened kick. Adjust heat by tweaking cayenne pepper amount.
Butter & garlic: Infuse the creamy alfredo sauce with tons of savory, aromatic goodness.
Heavy whipping cream: Key for that thick, luscious alfredo base that coats the roll-ups perfectly.
Parmesan cheese: Adds sharp, nutty depth and helps thicken the sauce.
Cream cheese & ricotta cheese: Make the filling irresistibly smooth, tangy, and rich.
Frozen chopped spinach: Drained well, it blends seamlessly into the cheese filling for balance and color.
Mozzarella & Colby Jack cheese: Melty, stretchy cheese that’s perfect for topping and stuffing inside the roll-ups.
Spices (smoked paprika, cayenne, onion powder, etc.): These create the complex blackened chicken seasoning — smoky, spicy, and savory all at once.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

One of the things I love most about this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe is how easy it is to customize. You can tone down the spice for the kids or swap in different cheeses for new flavor combos. It’s your canvas!

Variation: Sometimes I sub kale or Swiss chard for spinach — just make sure to drain it really well to keep the filling from watering down.
Dietary swaps: Use gluten-free noodles or lactose-free cream cheese and dairy alternatives if needed. The flavors still shine through!
Extra veggies: Roasted red peppers or sautéed mushrooms mixed into the filling add even more depth.
Spice level: Feel free to add more cayenne pepper to the blackening mix for a serious kick or cut it in half for a milder meal.

Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Prepping and Blackening the Chicken

Start by making your blackened seasoning blend — mixing smoked paprika, cayenne pepper, onion powder, brown sugar, garlic powder, black pepper, salt, thyme, and oregano. Pat your chicken dry, then rub each piece generously with olive oil and coat with the spice blend. Heat a skillet over medium-high heat, add olive oil, then sear chicken 4-5 minutes per side until cooked through and beautifully charred. Let it rest, then dice into bite-sized pieces.

Step 2: Cooking Lasagna Noodles and Preparing Filling

While the chicken cooks, boil your lasagna noodles just until al dente — you want them flexible but not falling apart. Drain and carefully lay them out flat on parchment or a kitchen towel. Next, mix cream cheese, ricotta, drained chopped spinach, diced chicken, a couple teaspoons of cajun seasoning, and about half of your shredded mozzarella and Colby Jack cheeses until smooth and well combined.

Step 3: Rolling and Filling Your Lasagna Sheets

Spoon a generous amount of the filling onto each noodle, then gently roll it up from one short end to the other. Place seam-side down in your greased 9x13 baking dish — they’ll fit snugly side by side.

Step 4: Making the Garlic Alfredo Sauce

In a saucepan over medium heat, melt butter and gently sauté minced garlic until fragrant. Pour in the heavy cream and cajun seasoning, simmering gently to thicken slightly. Stir in grated parmesan until melted and silky smooth — don’t rush this part or the sauce might separate.

Step 5: Baking to Golden Perfection

Pour the alfredo sauce over the lasagna roll-ups, then sprinkle remaining mozzarella and Colby Jack cheese on top. Bake uncovered at 375°F for about 35 minutes until bubbly and golden on top. Let it rest a bit before serving — this helps everything set so the rolls don’t unravel.

Top Tip

I learned the hard way that draining your spinach thoroughly and letting your chicken rest before dicing are absolute game-changers. These little steps totally affect the texture and moisture balance in the roll-ups, and trust me, it’s worth the extra minute.

Rest your chicken: After cooking blackened chicken, let it rest 5-10 minutes for juiciness and easier slicing.
Drain spinach well: Use a clean kitchen towel or fine mesh strainer and press out excess water to avoid soggy filling.
Cook noodles al dente: Overcooked noodles risk tearing when you roll, so keep a close eye.
Simmer alfredo sauce gently: Avoid boiling the cream; a gentle simmer helps keep sauce creamy without splitting.

How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Blackened Chicken Alfredo - Serving Suggestion

Garnishes

I usually sprinkle fresh chopped parsley and a bit more grated Parmesan right as the dish comes out of the oven — it adds a fresh pop of color and flavor. A light drizzle of olive oil or even a squeeze of lemon can brighten the richness if you want.

Side Dishes

This recipe pairs perfectly with garlic bread or Texas toast for mopping up any extra alfredo sauce. I also love serving it alongside a crisp Caesar salad or roasted asparagus for some green crunch to balance the creamy roll-ups.

Creative Ways to Present

For special occasions, I like arranging the roll-ups on a platter and drizzling a little extra alfredo and hot sauce for guests to add their own heat. A sprinkle of crushed red pepper flakes also adds a festive touch and some zing.

Make Ahead and Storage

Storing Leftovers

Leftover roll-ups store beautifully in an airtight container in the fridge for 3-4 days. I prefer to portion them individually so reheating is quick and easy without drying out the whole batch.

Freezing

You can freeze these roll-ups before baking by placing them in a single layer on a baking sheet to flash freeze, then transferring to a freezer bag. Bake from frozen adding extra 10-15 minutes to the cook time, covered with foil to prevent drying.

Reheating

Reheat leftovers covered in the oven at 350°F for 15-20 minutes until warmed through. Alternatively, microwave covered but in short bursts to avoid rubbery textures. I recommend adding a splash of cream or milk before reheating to keep it moist.

Frequently Asked Questions:

How spicy is the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe?

The spice level can be adjusted easily by changing the amount of cayenne pepper in the blackened seasoning. If you prefer mild, use less cayenne, and for more heat, add a bit more. The alfredo sauce also helps mellow out the spice for balance.

Can I use store-bought alfredo sauce instead of making it from scratch?

Absolutely! Store-bought alfredo sauce can be a great shortcut and still tasty, but homemade sauce offers fresher garlic flavor and a creamier texture. If using store-bought, consider warming it gently with extra garlic or parmesan to elevate the flavor.

What’s the best way to prevent the roll-ups from falling apart?

Make sure not to overcook the noodles and fill the rolls generously but not too full so they can roll tightly without tearing. Placing them seam side down in the baking dish also helps keep their shape during baking.

Can I prepare the Blackened Chicken Alfredo Lasagna Roll-Ups ahead of time?

Yes! You can assemble the roll-ups a day in advance and keep them covered in the refrigerator. Bring them to room temperature before baking, or bake straight from the fridge with an extra 5-10 minutes added to the baking time. This makes entertaining a breeze!

Final Thoughts

Making the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe has genuinely become a favorite in my kitchen because it hits every craving: creamy, spicy, cheesy, and comforting. It’s perfect when you want something a bit elevated but still feel like home cooking. I’m confident you’ll enjoy making (and eating) this as much as I do—so go ahead, roll up your sleeves and try it out!